Should I Give My Child Melatonin to Help Him Sleep?

A Reader Asks

Thanks for reading the very long post on Monday, and I’m glad some of you found it helpful. The comments on that post were illuminating and thoughtful. One thing a few of you disliked was the Ron DeSantis dig in what is not typically a political newsletter. Point taken! That particular frustration was one I heard often, so I was echoing it, but I hear how that came across. Limited politics! Got it. You can subscribe to other people’s newsletters for that.

Today, let’s do a non-COVID question, shall we? 


Hello Emily! 

I’m wondering if you have any research on how to help kids with difficulty going to bed? My son, who is 3.5 years old, has been repeatedly leaving his room after our bedtime routine. We have tried sticker charts, etc., but after a month of often 1.5-hour struggles, we tried melatonin, and he is out very quickly. We are thrilled with the results but wondering if it’s the best way — and also if there’s any research on giving melatonin to kids?

Nothing I like better than a data review question.

First things first: What is melatonin? Melatonin is a natural hormone responsible for helping us fall asleep and for regulating our circadian rhythms. It’s secreted by the pineal gland, part of the endocrine system. With less melatonin, sleep cycles are disrupted (this happens more as people age, for example, or with certain diseases).

The melatonin that you can buy over the counter, which is what we’re talking about here, is just a version of that hormone. Put very simply, it works by supplementing the hormones your body produces naturally. Melatonin is widely available over the counter or online — it comes in quick-release or delayed-release form, in gummies and pills. An important note, which I will return to later, is that this is a largely unregulated space, and the actual hormone concentration in over-the-counter options often varies from what is stated. This point will matter more for thinking about longer-term usage.  

Melatonin, in both kids and adults, is used for two primary sleep reasons. The first is jet lag or some other significant disruption in circadian rhythm. The second is general insomnia, especially “sleep onset” insomnia as described here, in which the issue is difficulty falling asleep in the first place. I’m going to talk about each of these in turn, since the way we’d think about them is a bit different. In both cases, the key questions are simple: Does it work, and is it safe?

Jet Lag

There is significant randomized controlled trial evidence supporting the use of melatonin to address jet lag in adults. There is an excellent Cochrane Review of trials (linked above), which ends with “Melatonin is remarkably effective in preventing or reducing jet lag, and occasional short-term use appears to be safe.”

In these data, adult doses in the range of 0.5mg to 5mg show similar impacts, likely arguing for using lower doses. A key is to take the medication close to the “target bedtime” (i.e. at night).  

There is limited direct evidence in children, although given the evidence from adults and the general principle, it seems extremely likely that children would also respond positively. Safety data on long-term use (again, below) suggests limited reason for concern. Children are likely to respond to a lower dose than adults, perhaps as little as 0.25mg.

Bottom line: As a short-term support for jet lag, melatonin may well be a good idea. 

Sleep Problems

The question asked above, though, isn’t about short-term use for jet lag but about longer-term use as a sleep aid. The answer to this is more complicated.

First, I should note that in The Family Firm I spend a lot of time talking about how important sleep is. We have good evidence, from randomized trial data and school start-time variation, that sleep is important for kids to function well, and that even an hour more or less can matter. So thinking about how to make bedtime go better isn’t just about limiting conflict or making the lives of parents easier; it’s also about getting your kid the better sleep they need.

Knowing this, I think, may push some parents to look to melatonin — which seems like a safe, natural option — as a way to improve bedtime. Indeed, when I spoke with a couple of pediatricians, they said this is an extremely common question. 

They made a point — the same point made in broader medical discussions of melatonin for children — that it shouldn’t be a first line of defense, nor is it a magic bullet. Giving your kid a dose of melatonin at 8pm probably isn’t going to suddenly move them from falling asleep at 11 to 8:30.

So before you turn to melatonin, it’s worth thinking through the other elements of bedtime. Is there a consistent and predictable bedtime routine for your kid? Are they going to bed at the “right” time for their age and sleep needs? If your child wakes up without trouble and seems well-rested during the day, they may just need a later bedtime. If your child is still napping during the day and then struggling to sleep at night, dropping the nap should be the first line. Finally: screens in the couple of hours before bed mess up sleep for kids. I talk about this in Family Firm, and there is good randomized evidence on it. 

This is all to say that before you consider melatonin, there are other steps first. (This is a general point, not an admonition to the letter writer above, since it sounds to me like they did think through these other steps.) In addition, melatonin is typically used to promote falling asleep, not continued sleep: The focus of efficacy is sleep-onset insomnia, so it is not likely to be the answer if your child is waking up in the middle of the night. 

Most of the evidence on melatonin and children focuses on children with neurodisabilities, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). There is a sense that some of the findings might well translate to neurotypical kids, but those populations aren’t well studied. 

On the question of efficacy, this review and meta-analysis covers 11 trials with about 600 children. The trials, when put together, show evidence of the efficacy of melatonin in promoting sleep. The effects are especially large in children with ASD (versus those with other neurodevelopmental disorders). The average sleep increase is about 15 minutes, which may seem small but means a longer increase in some kids. 

We always worry about medications, and in this case concerns have been raised about interactions between treatment with melatonin and the function of the natural endocrine system. However: safety data on long-term use (also focused on children with neurodisabilities) has argued that there is evidence of safety in the short and long term (or rather, that it is “well tolerated”). There is little positive evidence to support concerns about interactions with puberty timing. Having said this, we do not have any kind of significant evidence on long-term use in neurotypical kids. This makes it difficult to substantiate claims of either safety or harm. 

Typical dosing for melatonin is in the range of 1 to 3 mg, given shortly before bedtime.  

Two very important notes. First, any long-term (or even probably short-term) use of melatonin is a discussion to have with your pediatrician. Second, testing in many over-the-counter melatonin options suggests that the concentration in many cases differs widely from what is advertised. Pharmaceutical-grade melatonin is also available over the counter but with more consistent dosing. For longer-term use, this option would be appropriate.  

The Bottom Line

Pulling all this together:  

  • Short-term use of melatonin for jet lag and short-term sleep disruptions: good evidence of efficacy and limited concerns

  • Long-term use for sleep-onset insomnia: definitely not without pediatrician discussion, and not a first line for neurotypical children; may be appropriate in some circumstances

There is an intermediate answer in here for the question asker. It sounds like the melatonin has really worked where other options didn’t. In this sense, “data” on efficacy from broad studies isn’t really necessary, since you know it works. It’s likely that you’re reluctant to use it forever, though. I might approach this as probably short-term use, with a planned experiment of weaning off down the line.


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